"Normal Tissue Firewall" in Health and Disease- Dr. Rao Papineni

Normal Tissue Care During Disease Cure

Normal Tissue Protection - A Firewall

I delivered three Invited seminars recently at International Conferences organized by three different societies in Madras (Currently Chennai), Hyderabad, and Bangalore.  

Details of these three talks were carried out by a local Newsgroup.  This is the second of the three talks I shared with them..

The talk was focused on:

"Normal Tissue Firewall" in Health and Disease.  

and that Protection of Normal Tissue a MUST (?) during Cure, CT Scans, Air Travel, X-Ray scans, Nuclear Medicine, Cancer treatment, Chemotherapy.

Dr Rao Papineni of Connecticut USA is presenting an invited talk at the AMPICON 2016 on 19th November.  This being the 40th year of the Indian Medical Physicists Association, Hyderabad Meet, will be monumental.  Medical physicists are as critical as Surgeons and Physicians when it comes to Patient care.  Dr. Papineni will bring in the "Systems Radiopharmacology" to the forefront.  A program and paradigm to advance better cure with care to "Normal Tissue".  

Normal tissue toxicity is a major issue during Cancer treatment which in lay terms are addressed as side effects.  A young patient who survives the cancer may live with the chemo or radiation after-effects on the Normal tissue for several decades compromising the quality of life.  Most of the time, it's so drastic that, the cancer survivor in the middle of a routine grocery purchase may involuntarily excrete fecal matter.  Apart from the gastrointestinal problems, bladder control, erectile dysfunction, cardiovascular issues may add on depending on the type of cancer and its treatment. 

Yes!  Drugs and new technologies will prevent Normal Tissue Toxicity.  Here, lot of research efforts are in progress globally.  CT scans, dental Imaging, airport screening, high altitude flying, and nuclear accident exposure come under the umbrella of contributors to Normal Tissue Toxicity. Therefore "Normal Tissue firewall" is imperative.  

Dr, Papineni last week at Madras (Chennai) was part of a Panel Discussion moderated by Dr. Norm Coleman of NCI, USA. The panel discussed about ways to improve the Normal Tissue protection.   Here, experts and thought-leaders from different countries met at Raintree Hotel for IBIBAM 2016.  Dr Rao Papineni at the deliberations pointed to the potential of patient's prior history of infection, injuries, inflammation and other pathologies in influencing the severity of "Normal Tissue Toxicity". 

Dr Rap Papineni's Talk gist at AMPICON is below

Systems Radiopharmacology- Physics and Radiation Pharma.

Dr. Rao V. L. Papineni

Papineni@graduate.hku.hkpapineni@graduate.hku.hk

Akin to Hippocrates’s quote “All disease begins in the gut”, carcinogenesis, bacterial infection, mechanically-induced inflammation, and X-Ray radiation toxicity present similar pathological response at the GI.  With the rapid developments in biophotonic tools, visualizing physiological events in real time is made possible with greater accuracy.  Especially like angiogenesis, brain activity, tumor development and its vascularization, radiation injuries and its responsive radiobioluminescence.  Added, novel transgenic mice with transcription factor activity driven genetic reporting opened new facets in genetic and signaling networks.  These developments present opportunities to monitor responses of a living organism to exposure to different pathogens, stresses and diseases. Particularly, in vivo visualization of oxidative stress shows that excessive production of reactive oxygen species (ROS) is implicated in an early phase of different pathologies and physiological states.  This indicates that the oxidative stress from the different pathological processes noted above, responds and converges on ROS upregulation and induction of oxidative stress response.  The similar genotoxic stress response of GI microenvironment to different pathologies also suggest a link between inflammatory/immunity and cancerogenesis, where various cells within the abdominal microenvironment are involved.  There is a close cooperation and cross talk among GI epithelia cells, intestinal stem cells, macrophages, GI microbiota and vagal sensory neurons, which are involved in oxidative stress response to bacterial pathogen at the cellular and organism levels.  The sequence of events is relatively similar during GIinjury as a result of radiotherapy.  Overall, it is tempting to conclude that the Thiol Switches/Keys indeed propagate the downstream molecular melody for maladies.  In this talk, the crosstalk and communication amongst cells making up the complex GI microenvironment during responses to pathogens and radiation injuries will be discussed.  Further, review how a deeper understanding of the role of ROS in pro- and anti- inflammation signaling and immune modulation through such collaborative investigation lead to the design of effective treatment strategies and drug repurpose countermeasures against GI damage induced by chronic inflammation and GI radiation injuries.  

Dr. Rao V. L. Papineni

Professor (Adjunct- assistant)

University of Kansas Medical Center KUMC

USA

Dr. Rao V. L. Papineni is an Adjunct faculty member at University of Kansas Medical Center, and a molecular theragnostics scientist at PXI,  USA. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Master’s Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined Kodak/Carestream Health, USA.  Dr. Papineni has made several inventions and chaired scientific sessions in International Biomedical Meetings and serves on the editorial board of Nanotech and Experimental Pharmacology journals.  As a distinguished scientist, he initiated advanced research programs to study Inflammation and oncology utilizing molecular imaging and nanotechnology based molecular tools.  He recently identified and coined “Radiobioluminescence” a novel X-ray induced radiation phenomena that have immense potential in development of cancer therapeutic strategies.  His lab is instrumental in development of MIGRT  Molecular Image Guided Radiation Therapy technology and utilizing radiobiophotonics and MIGRT in Drug Discovery related to Cancer and radiation medicine.

http://www.chennaicitynews.net/news/normal-tissue-care-during-disease-cure-dr-rao-papineni-35239/ 

His lab is instrumental in development of MIGRT Molecular Image Guided Radiation Therapy technology and utilizing radiobiophotonics and MIGRT in Drug Discovery related to Cancer and radiation medicine.