Thursday, November 2, 2017

Pink City, Radiobiophotonics and Normal Tissue Toxicity- Firewall

 

Pink City, Radiobiophotonics and Normal Tissue Toxicity

 AOCPM- AMPICON 2017-  Mini-Symposia

Dr. Rao V. L. Papineni

 



Association of Medical Physicists of India (AMPI) and Asia Oceania Federation of Organizations for Medical Physics (AFOMP),  jointly hosts 17th Asia Oceania Congress of Medical Physics (AOCMP 2017) and 38th Annual Conference of Association of Medical Physicists of India (AMPICON 2017)  at SMS Medical College and Hospitals, Jaipur, “Pink City” from 4th to 7th November 2017.
The theme for the conference is “Advances in Medical Physics: shaping the future of modern healthcare“. 




In response to the invitation, I have organized two mini-symposia at the conference.
1. Radiobiophotonics 
2. Normal Tissue Toxicity- Firewall.


Mini Symposia  on novel emerging topics of Radiological Physics is designed by organizers as part of the conference. The symposiums obviously will cover topics of Radiation Biology, Quality Assurance (QA), Radiation Protection, TG reports, Radiomics of cancer, Molecular Imaging and advanced techniques in diagnostics and therapy.


Radiobiophotonics & Normal Tissue Toxicity.  
Symposium Coordinator & Speaker:  Dr. Rao V. L. Papineni 
Authors: Rao Papineni & Shahid Umar
University of Kansas Medical Center, PXI. Inc, and PACT & Health USA


Visualization via "light" coupled with "ionizing radiation" has made a profound impact both in understanding the disease mechanism and its treatment.  Rapid advances in photonics also aided in bridging the physics and medicine towards the new front in Cancer Radiation Therapy.  This Session brings to forefront "Radiobiophotonics" bringing to fold the rapidly growing fields pertaining to biophotonics in relation to radiobiology and Radiation Therapy.  These fields, Molecular Image Guided Radiation Therapy (MIGRT), X-Ray Luminescence,  Radiobioluminescence, Microscopy, Cherenkov Luminescence and it's role in microdosimetry, metastatic tumor phototherapy, activated nanodelivery and particle therapy beam tracking will be discussed.  The normal tissue toxicity assessment during radiation therapy or Nuclear Accidents using Radiobiophotonics will be elaborated.   Epithelial regeneration model will be used to describe the use of photonics in assessing Normal tissue injury and pharmacological intervention.  Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base columnar ISCs for normal epithelial maintenance.  Little is known about the regulation of the ISC compartment after tissue damage. Exposure to high doses of radiation triggers a number of potentially lethal effects. Among the most severe is the gastrointestinal (GI) toxicity syndrome caused by the destruction of the intestinal barrier, resulting in bacterial translocation, systemic bacteremia, sepsis and death.  The pathophysiological downstream events and the search of effective radioprotective agents by us will be highlighted.  Further this symposia will describe the significance of such radiation pharma interventions as effective emergency nuclear countermeasures not only for patients undergoing abdominal irradiation for GI malignancies but to promote survival and delay mortality for victims of radiation exposure and nuclear disasters.

Other faculty at AMPICON 2017:
 International Faculty
 National Faculty

Jaipur “Pink city of India is most celebrated city of legendary Rajputana, the land of Rajput valour, still retains its beauty and charm despite the process of modernization. It was founded in 1727 AD by one of the great rulers of Kachhawaha clan, the astronomer king Sawai Jai Singh II and still retains its splendid valor.  Jaipur is is the capital city of Rajasthan and Rajasthan is perhaps the most tribally diverse, artistically decorative and architecturally magnificent regal in India. It is the land of royalty with lavish forts and majestic palaces that are apt reminder of a rich and romantic past that speaks of heroism, honor and chivalry. 

 Look forward to meeting friends and Colleagues.   

Papineni Labs are Biomedical Research Labs in Honor of my Father Mr. Papineni Venkateswara Rao.



    "Molecular Imaging - Wisdom to See for Maladies to Flee"
                                                         
                                                                                   Dr. Rao V. L. Papineni






Dr. Rao V. L. Papineni
Professor (Adjunct- assistant)
University of Kansas Medical Center KUMC
USA
Dr. Rao V. L. Papineni is an Adjunct faculty member at University of Kansas Medical Center, and a molecular theragnostics scientist at PXI,  USA. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Master’s Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined Kodak/Carestream Health, USA.  Dr. Papineni has made several inventions and chaired scientific sessions in International Biomedical Meetings and serves on the editorial board of Nanotech and Experimental Pharmacology journals.  As a distinguished scientist, he initiated advanced research programs to study Inflammation and oncology utilizing molecular imaging and nanotechnology based molecular tools.  He recently identified and coined “Radiobioluminescence” a novel X-ray induced radiation phenomena that have immense potential in development of cancer therapeutic strategies.  His lab is instrumental in development of MIGRT  Molecular Image Guided Radiation Therapy technology and utilizing radiobiophotonics and MIGRT in Drug Discovery related to Cancer and radiation medicine.

Tuesday, September 12, 2017

Cancer Warriors & Radiobiophotonics - Dr. Rao Papineni

Cancer Warriors and Radiobiophotonics at Cancun RRS 2017


Initiating this blog on 9/11 Remembrance Day, would like to share some of our recent events and also the program ahead from my lab.

Late Breaking Presentation
We are pleased to share that the "Late Breaking" Research submission
Title: "Focused irradiation of EDL muscle bundle and functional study- a feasibility study.
 Dr. Rao Papineni & Dr. George Rodney
was accepted at the  Radiation Research Society  (RRS 2017) Meeting at Cancun.  This Work from Papineni & Rodney Labs will showcase the Feasibility & the Novel Approach in Assessing Radiation Effects on individual Muscle.  With one in three cancer patients loosing the battle due to muscle related issues, this technological advance will be crucial in future mitigation studies. This work will highlight the design and development of a miniaturized X-ray muscle Irradiation system.
#Cachexia #MuscleAtrophy #X-Ray  

The 63rd Annual Meeting of the Radiation Research Society is to be held at the Grand Fiesta Americana Coral Beach in Cancun, Mexico on October 15-18, 2017. The scientific program covers state-of-the-art in radiation sciences with an emphasis on Translating Radiation Research: From Risk to Therapy.  Here, I had the privilege to design and develop a symposium on a new and growing field of Radiobiophotonics.

SYMPOSIUM  Recent Advances in Radiobiophotonics, Nanomedicine and Imaging
  
Chair: Dr. Rao Papineni



Look forward to seeing many of you at Cancun.


Finally, adding the short article that was requested by a Tabloid to showcase the 25 year achievement in grooming young minds towards advance science, medicine and innovation.

 http://www.chennaicitynews.net/news/nextgen-cancer-warriors-in-making-by-dr-rao-v-l-papineni-53722/

               
              NextGen Cancer Warriors in Making
                                    by Dr. Rao V. L. Papineni
 
The bitter truth is that cancer the deadly human scourge will plague humanity for generations to come.  We might have to chalk out Moonshot, Mars, and Jupitershot battles with time, to win this war.  A silent movement has been taking place at scores of research labs to coax, cajole, and entice young minds to get baptized into Cancer Research.  We invite High School students and impart scientific knowledge, training, and encouragement grooming them for future science and medicine program.  High school/college students join my laboratory or Papineni Labs Projects elsewhere during summer as interns and broaden their horizons. We are proud to celebrate 25th summer in training young minds akin to gurukul traditions.  At every opportunity, I keep remembering my favorite teacher (Hindi) Mr. K. Sridhar from Hindu Theological high School, Madras.  He used to inculcate us with appropriate slokas the power and value of knowledge transfer and to train students. 
The bitter truth is that cancer the deadly human scourge will plague humanity for generations to come.
It all started when my mentor Prof. Tom Boyde at University of HongKong asked me one summer day early 1990’s to draft a plan and proposal to train a summer student from Eton College, United Kingdom.  Thus I started with this heart-warming knowledge transfer program.  Though all students did not directly work on cancer related projects, they definitely had scope to pursue oncology ahead.  I still recall the first mini-project Jonathan Leong of Eton worked on-  To trick the immune machinery in making better affinity antibodies.  Simple idea back in 90’s I believed, turns out a useful path for current cancer immunotherapy.
Dr.Jyotsna Rao with Arnav and Pranayi
  They themselves have their own robust summer training programs.  This summer turned out to be exciting with couple of high school students Arnav Sankaranthi of Fremont, California, and Ms. Pranayi Pala of Dallas, taking courage and embarked on a trans-continental trip to work on a collaborative project on Radiomics.  They both joined Dr. Jyotsna Rao at Apollo Hospital India learning all about cancer Diagnostics while working on other project.  Both these kids accomplished quite a lot during the 2- week program and are working on a short review article.  Earlier this summer, Arnav along with his twin brother Abhinav  Sankaranthi and Ms. Somya Moyya of UCSD went through training at Dr. George Rodney’s lab at Baylor College of Medicine, Houston. 


                 students/interns                                                                                                                         

  There is no clear data; however I believe these summer research programs going on for decades all over the globe have generated great cancer warriors.  The cross-border and trans-continental training programs will add new perspectives and sharpen the skills of the young minds. It’s time to collaborate, exchange ideas and skills in this combat.   Cancer: the horrid scourge is not invincible.   
In an Industry setup, my lab had more opportunities to young minds from different walks of life. I am grateful to my friends and collaborators Dr. Shahid Umar of KUMC, Dr. George Rodney, Baylor College of Medicine, Dr. Jyotsna Rao, Apollo Hospitals, and others who help in this process.


Summer Science and Lab Fun



Dr. Rao V. L. Papineni is an Adjunct faculty member at University of Kansas Medical Center, and a molecular theragnostics scientist at PXI,  USA. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Master’s Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined Kodak/Carestream Health, USA.  Dr. Papineni has made several inventions and chaired scientific sessions in International
















Papineni Labs are Biomedical Research Labs in Honor of my Father Mr. Papineni Venkateswara Rao.



    "Molecular Imaging - Wisdom to See for Maladies to Flee"
                                                         
                                                                                   Dr. Rao V. L. Papineni