Pink City, Radiobiophotonics and Normal Tissue Toxicity- Firewall

 

Pink City, Radiobiophotonics and Normal Tissue Toxicity

 AOCPM- AMPICON 2017-  Mini-Symposia

Dr. Rao V. L. Papineni

 

Association of Medical Physicists of India (AMPI) and Asia Oceania Federation of Organizations for Medical Physics (AFOMP),  jointly hosts 17th Asia Oceania Congress of Medical Physics (AOCMP 2017) and 38th Annual Conference of Association of Medical Physicists of India (AMPICON 2017)  at SMS Medical College and Hospitals, Jaipur, “Pink City” from 4th to 7th November 2017.
The theme for the conference is “Advances in Medical Physics: shaping the future of modern healthcare“. 

In response to the invitation, I have organized two mini-symposia at the conference.

1. Radiobiophotonics 

2. Normal Tissue Toxicity- Firewall.

Mini Symposia  on novel emerging topics of Radiological Physics is designed by organizers as part of the conference. The symposiums obviously will cover topics of Radiation Biology, Quality Assurance (QA), Radiation Protection, TG reports, Radiomics of cancer, Molecular Imaging and advanced techniques in diagnostics and therapy.

Radiobiophotonics & Normal Tissue Toxicity.  

Symposium Coordinator & Speaker:  Dr. Rao V. L. Papineni 

Authors: Rao Papineni & Shahid Umar

University of Kansas Medical Center, PXI. Inc, and PACT & Health USA

Visualization via "light" coupled with "ionizing radiation" has made a profound impact both in understanding the disease mechanism and its treatment.  Rapid advances in photonics also aided in bridging the physics and medicine towards the new front in Cancer Radiation Therapy.  This Session brings to forefront "Radiobiophotonics" bringing to fold the rapidly growing fields pertaining to biophotonics in relation to radiobiology and Radiation Therapy.  These fields, Molecular Image Guided Radiation Therapy (MIGRT), X-Ray Luminescence,  Radiobioluminescence, Microscopy, Cherenkov Luminescence and it's role in microdosimetry, metastatic tumor phototherapy, activated nanodelivery and particle therapy beam tracking will be discussed.  The normal tissue toxicity assessment during radiation therapy or Nuclear Accidents using Radiobiophotonics will be elaborated.   Epithelial regeneration model will be used to describe the use of photonics in assessing Normal tissue injury and pharmacological intervention.  Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base columnar ISCs for normal epithelial maintenance.  Little is known about the regulation of the ISC compartment after tissue damage. Exposure to high doses of radiation triggers a number of potentially lethal effects. Among the most severe is the gastrointestinal (GI) toxicity syndrome caused by the destruction of the intestinal barrier, resulting in bacterial translocation, systemic bacteremia, sepsis and death.  The pathophysiological downstream events and the search of effective radioprotective agents by us will be highlighted.  Further this symposia will describe the significance of such radiation pharma interventions as effective emergency nuclear countermeasures not only for patients undergoing abdominal irradiation for GI malignancies but to promote survival and delay mortality for victims of radiation exposure and nuclear disasters.

Other faculty at AMPICON 2017:

 International Faculty

http://aocmp-ampicon2017.org/?page_id=3392

 National Faculty

http://aocmp-ampicon2017.org/?page_id=4459

Jaipur “Pink city of India” is most celebrated city of legendary Rajputana, the land of Rajput valour, still retains its beauty and charm despite the process of modernization. It was founded in 1727 AD by one of the great rulers of Kachhawaha clan, the astronomer king Sawai Jai Singh II and still retains its splendid valor.  Jaipur is is the capital city of Rajasthan and Rajasthan is perhaps the most tribally diverse, artistically decorative and architecturally magnificent regal in India. It is the land of royalty with lavish forts and majestic palaces that are apt reminder of a rich and romantic past that speaks of heroism, honor and chivalry. 

 Look forward to meeting friends and Colleagues.   

Papineni Labs are Biomedical Research Labs in Honor of my Father Mr. Papineni Venkateswara Rao.

http://www.radres.org/blogpost/961725/250704/Cancer-Therapy--Radiobiophotonics-with-Rao-Papineni
 

    "Molecular Imaging - Wisdom to See for Maladies to Flee"
                                                                                                                                             Dr. Rao V. L. Papineni

Dr. Rao V. L. Papineni

Professor (Adjunct- assistant)

University of Kansas Medical Center KUMC

USA

Dr. Rao V. L. Papineni is an Adjunct faculty member at University of Kansas Medical Center, and a molecular theragnostics scientist at PXI,  USA. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Master’s Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined Kodak/Carestream Health, USA.  Dr. Papineni has made several inventions and chaired scientific sessions in International Biomedical Meetings and serves on the editorial board of Nanotech and Experimental Pharmacology journals.  As a distinguished scientist, he initiated advanced research programs to study Inflammation and oncology utilizing molecular imaging and nanotechnology based molecular tools.  He recently identified and coined “Radiobioluminescence” a novel X-ray induced radiation phenomena that have immense potential in development of cancer therapeutic strategies.  His lab is instrumental in development of MIGRT  Molecular Image Guided Radiation Therapy technology and utilizing radiobiophotonics and MIGRT in Drug Discovery related to Cancer and radiation medicine.

Turmeric a Medicine - Enigmatic Medicinal Actions

        Turmeric a Medicine - Enigmatic Medicinal Actions

            Papineni Labs     Curcumin Infection Treatment - Clinical Imaging

Turmeric is a Medicine - established through centuries by a unique class of researchers practicing Ayurveda, Siddha, and other old world medicine.  Curcumin is a compound in turmeric with the golden medicinal property.   Pongal and Sankaranthi are major Indian Harvest Festival where turmeric is copiously used by everyone.  One can see loads of young turmeric all over the wet market.    

Waking up on this Pongal Day, I was really disappointed to see the following commentary titled “Deceptive curcumin offers cautionary tale for chemists” in one of the premier research journal http://www.nature.com/news/deceptive-curcumin-offers-cautionary-tale-for-chemists-1.21269.  The author of the commentary states that the turmeric extracts dupes assays and leads drug hunters astray.  The commentary highlights the review (K. M. Nelson et al. J. Med. Chem. http://dx.doi.org/10.1021/acs.jmedchem.6b00975; 2017), published on 11 January.  Here, the authors published a most comprehensive critical review on curcumin.  Their conclusions - no evidence in curcumin’s therapeutic benefits, despite thousands of research papers and more than 120 clinical trials is a big Jolt!  Sad to notice this auspicious root is getting a bad rap due to improper research approaches applied by many laboratories in evaluating the curcumin drug action mechanisms.  In many cases, sloppy science is a factor as discussed by the contributors of the above works.

This turmeric compound spreads its wings with a predatory effect on a billion dollar market in cure of a range of diseases from erectile dysfunction, hirsutism, baldness, cancer and Alzheimer’s disease. In fact, big establishments can go curries in this golden concoction.    

Everyone agrees turmeric has all the potential to be a true multi-tasking drug.  It’s just that, meticulous biochemical and pharmacological approaches aided with the cutting-edge molecular imaging and high-throughput assays need to be followed.  Here is a compound, Gold, that took a millennium to establish its medicinal properties in the east – scientific community can’t just throw hands up in despair and walk away within a decade. 

In Papineni Labs, my first attempt with curcumin on human skin disorder was promising. We designed and developed a Clinical Molecular Imaging System for early detection of cardiovascular changes in diabetes and other diseases http://www.fasebj.org/content/25/1_Supplement/815.13.short.  Using this first of its kind clinical optical imaging instrument, we tested effects of curcumin on ringworm infection as a proof-of-principle.  Ringworm is a common fungal infection that appears as patches of red ring on the skin.  We used the near infrared fluorescence (NIRF) imaging to image the infection and subsequent treatment using topical curcumin application.  In this work, non-invasive autofluorescence imaging was performed utilizing the natural fluorescence resultant of the fungal infection. Curcumin showed a success where over- the-counter and prescription drug treatments failed with a subject.  Curcumin did show a promise, a larger sample size and additional methodologies are needed to nail the mode of action. We reported this fluorescence based methodology at the World Molecular Imaging Congress WMIC 2011 San Diego, USA and in Bhubaneshwar (Society of Nuclear Medicine- India 2012).

Yes, our ancestors were right in terms of the medicinal properties of turmeric.  It is just quite complex to isolate the primary compounds from this elixir and to dissect its mode of action.  Not impossible, especially with developments in Imaging, animal models, mass spectrophotometers, and high throughput drug screening methods in hand.  

Madras (Chennai) News Item:

'

http://www.chennaicitynews.net/turmeric-is-medicine-dr-rao-v-l-papineni/

 

Dr. Rao V. L. Papineni

Professor (Adjunct- assistant)

University of Kansas Medical Center KUMC

USA

Email: Papineni@graduate.hku.hk

Dr. Rao V. L. Papineni is an Adjunct faculty member at University of Kansas Medical Center, and a molecular theragnostics scientist at PXI,  USA. He received his doctoral degree in Biochemistry from University of Hong Kong (British Terr). Dr. Papineni had his early education from University of Madras, where he earned his Bachelors and Master’s Degree. After ten years in Research and Faculty positions at University of Hong Kong and Baylor college of Medicine (USA), he joined Kodak/Carestream Health, USA.  Dr. Papineni has made several inventions and chaired scientific sessions in International Biomedical Meetings and serves on the editorial board of Nanotech and Experimental Pharmacology journals.  As a distinguished scientist, he initiated advanced research programs to study Inflammation and oncology utilizing molecular imaging and nanotechnology based molecular tools.  He recently identified and coined “Radiobioluminescence” a novel X-ray induced radiation phenomena that have immense potential in development of cancer therapeutic strategies.  His lab is instrumental in development of MIGRT  Molecular Image Guided Radiation Therapy technology and utilizing radiobiophotonics and MIGRT in Drug Discovery related to Cancer and radiation medicine.

 

http://www.radres.org/blogpost/961725/250704/Cancer-Therapy--Radiobiophotonics-with-Rao-Papineni
 
"Molecular Imaging - Wisdom to See for Maladies to Flee"
                                                          Dr. Rao V. L. Papineni